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KMID : 0616120170480030219
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 3 p.219 ~ p.225
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Anti-oxidative Effect of Blueberry Duke Extract in Caenorhabditis elega
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Kim Jun-Hyeong
An Chang-Wan
Kim Yeong-Jee
Noh Yun-Jeong
Kim Su-JIn
Jeong Seong-Yeop
Jeong Do-Youn
Hwang In-Hyun
Kim Dae-Keun
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Abstract
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We investigated the anti-oxidative effect of the blueberry duke (Vaccinium corymbosum L., Ericaceae) ethanol extract in Caenorhabditis elegans model. The ethanol extract of blueberry duke showed relatively significant DPPH radical scavenging and superoxide quenching activities. To prove antioxidant activity of the extract, we checked the activities of superoxide dismutase (SOD), catalase, intracellular ROS, and oxidative stress tolerance in C. elegans. In addition, to verify if the increased stress tolerance of C. elegans by treating with the extract was due to regulation of stress-response genes, we checked SOD-3 expression using a transgenic strain. As a consequence, the blueberry duke ethanol extract increased SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose-dependent manner. Besides, blueberry duke ethanol extract-treated CF1553 worms showed higher SOD-3::GFP intensity.
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KEYWORD
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Vaccinium corymbosum L. , Caenorhabditis elegans , Anti-oxidative effect , SOD , ROS
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